Goode’s other achievements include being named European Player of the Year in 2019.
“To the coaches and all the backroom staff, you are the core of the club, you have supported me always and I can’t thank you enough for your time and energy,” he said.
“To my team-mates, past and present, it’s been an unreal ride, and I’ll carry those memories and bonds with me for the rest of my life.
“To the fans, you’ve stood by us through glory and heartbreak with unwavering faith. To hear your roar on my 400th game, seeing those faces, means more than you’ll ever know.
“I leave the field with no regrets, only gratitude. Saracens will always be in my blood.”
Director of rugby Mark McCall added: “There are few words left to truly capture the impact someone like Alex Goode has had not just at Saracens, but on the game of rugby as a whole.
“He will undoubtedly go down as one of the most successful players of the professional era.
“Goodey will always be remembered as a great team man, someone who went out of his way to help and support his team-mates. Our younger players have benefited enormously from his wisdom and guidance.”
Saracens, who are sixth in the Premiership table, face Bath at home on Saturday in their final game of the league season.
